Mindfulness – new directions in research into itching

The agonizing itching suffered by neurodermatitis patients is a major treatment challenge for both patient and clinician. As well as several other influential factors, stress can also have a negative impact on the course of neurodermatitis. Mindfulness-based stress reduction (MBSR) programmes can demonstrably reduce stress and the consequences of stress. Hence a study initiated by CK-CARE is addressing the question of whether practising mindfulness can have a positive effect on the disease course of neurodermatitis and the itching.

As part of a pilot study, in addition to state-of-the-art dermatological interventions, a classic MBSR programme and neurodermatitis training with elements of mindfulness-based stress reduction were carried out in neurodermatitis patients in the sense of a health-promoting measure. The aim was to study the feasibility (acceptance of the programme, dropout analysis, etc.) and to obtain initial evidence of the effectiveness of both programme components separately and in comparison with each other.

The pilot study was based on a classic pre-post comparison of two mindfulness-based programmes with n = 10 and n = 9 participants. In addition, data were recorded three months after the intervention in terms of a follow-up survey. As well as established measuring instruments in dermatology (SCORAD, DLQI, POEM), two established mindfulness questionnaires (MAAS and FMI) and two instruments for recording stress and strain (PSQ and HADS) were used. Furthermore, open and specific questions were employed in order to assess the benefit and effectiveness of the programmes.

Whereas no significant changes were seen in the dermatological and psychological measurements, the self-assessed attentiveness significantly increased in the first group. In the second group, on the other hand, an increase in inattentiveness was noted, which is a common observation following a systematic mindfulness-based programme. However, the acceptance and subjective rating of the programme as well as the participants’ satisfaction proved very positive.

Conclusion
Mindfulness-based interventions in the sense of health-promoting measures are useful and promising for the symptomatic treatment of itching in terms of generic stress and symptom reduction. The majority of the participants report that the programme helped them to deal better with the symptoms of the illness.

Global Allergy Forum 2022

The 4th Davos Declaration: A Milestone for Atopic Dermatitis Patient Care

During the last Global Allergy Forum (GAF) key opinion leaders from science, medicine and industry met in Davos to discuss the current state of the art of patient care in atopic dermatitis (AD) and proposed new strategies for its improvement. The thinktank addressed the high prevalence of AD and strategized methods to advance research, diagnostics, management and prevention. The findings are now published as «Navigating the Evolving Landscape of Atopic Dermatitis: Challenges and Future Opportunities: the 4th Davos Declaration».

Annual Report CK-CARE 2023

CK-CARE’s work has global resonance and, thanks to this strong position, significant projects in clinical allergy research were again launched or catalysed in the reporting year. CK-CARE’s working methods were sharpened in terms of medical translation and a strengthening of research capacities on the medical campus in Davos was defined in order to increase CK-CARE’s performance.

Annual Report 2023

CK-CARE’s work now has global resonance and, thanks to this strong position, significant projects in clinical allergy research were again launched or catalysed in the reporting year. CK-CARE’s working methods were sharpened in terms of medical translation and a strengthening of research capacities on the medical campus in Davos was defined in order to increase CK-CARE’s performance.

Kühne-Foundation Annual Report 2023

“Entrepreneurial success should go hand in hand with the promotion of  the common good. The Kühne Foundation fulfills this task. With a variety of programs and projects, the founder and the Kühne Foundation also assume their socio-political responsibility.”

The activities were significantly expanded, particularly in the area of logistics. In addition, the new focus area of climate action was established, and the first projects were launched.

Prof. Dr. h.c. Klaus-Michael Kühne

 

How flexible are neutrophils to opposing signaling?

Paola Martinez Murillo a postdoctoral researcher in Pierre-Yves Mantel’s group from CK-CARE obtained a Spark grant from the SNSF to investigate the effect of opposite signals on neutrophil biology in atopic dermatitis.

Spark is a Swiss National Science Foundation (SNSF) funding scheme aiming to support projects that show unconventional thinking and introduce a unique approach. The Spark is highly competitive and supports projects based on promising ideas of high originality. CK-CARE was recognized as an eligible institution in June 2023 by the SNSF, opening new funding opportunities for the CK-CARE researchers.

This project aims to understand how two opposing signals: eczema dysregulated immune environment (Th2 response) and bacterial colonization (Th1 response) impact neutrophils function.

Neutrophils are tiny but powerful immune cells in our blood that fight off bacteria and viruses. They live for only 2-3 days and can quickly respond to infections. Neutrophils can adapt to different situations thanks to their genetic instructions (RNA). Our body’s reversible changes in reading DNA, called epigenomic modifications, are crucial for a functional immune response.

Eczema, a chronic skin condition, happens when various factors like genetics, skin damage, and immune reactions go haywire. People with eczema have neutrophils that do not work as well in fighting bacteria, making them more prone to infections.

This study addresses a knowledge gap in neutrophil adaptation to an allergic milieu, by evaluating neutrophil adaptation to anti-bacterial response in a type 2 immune response dominated context such as atopic dermatitis using transcriptional and epigenomic profiling along with comprehensive analysis of neutrophil functionality (netosis, phagocytosis, ROS-production, bactericidal activity, chemotaxis). Building upon in-vitro stimulation insights, then we will aim for a comprehensive analysis of neutrophil functionality in atopic dermatitis patients treated or not with Dupilumab.

Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort

The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We conducted a cross-sectional study to investigate local environmental exposure and concomitant prevalence of allergic sensitization among local school children born and raised in an alpine environment.

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