“Commitment to Change” – how can CPD be translated into improved practice management of allergy patients?

Effectiveness and sustainability of Continuing Professional Development (CPD) courses are a major challenge. For the first time a Commitment-to-Change (CTC) strategy was applied by Doris Straub Piccirillo, MME Unibe, Head of CK-CARE CPD, within the course “Allergy in everyday paediatric practice”. This helped participants to put into practice what they had learnt on the course and also helps in programme planning. In addition, the question of why paediatricians alter their practice behaviour after the course was explored in a qualitative study.

It requires more than pure knowledge transfer for doctors to change their behaviour in practice as a result of CPD. Although today’s CPD events increasingly focus on the learners and are becoming more targeted in other ways, it remains a challenge to translate the acquired knowledge into everyday practice. One of the reasons for this is that typically CPD courses are not directly linked to changes in the attending physician’s behaviour or to patient outcomes.

Consistently employing a CTC strategy offers a new solution in this respect. CTC is based on a pragmatic, uncomplicated and easy-to-use model which makes the user more aware of personal goals and values and also provides incentives for action.

In English-speaking countries CTC has proved a successful means of stimulating processes of change, but in German-speaking Europe (Germany, Austria, Switzerland) this strategy is a new tool in medical CPD. Doctors take part in CPD programmes for a wide variety of reasons: to consolidate existing knowledge or keep up-to-date with the latest knowledge, to acquire new knowledge or learn new skills, to coordinate procedures and practices or simply to meet their obligation to undertake CPD. They invest time and money to do this. Therefore CPD programmes should basically be structured, effective and designed with a view to achieving sustainable improvements.

Global Allergy Forum 2022

The 4th Davos Declaration: A Milestone for Atopic Dermatitis Patient Care

During the last Global Allergy Forum (GAF) key opinion leaders from science, medicine and industry met in Davos to discuss the current state of the art of patient care in atopic dermatitis (AD) and proposed new strategies for its improvement. The thinktank addressed the high prevalence of AD and strategized methods to advance research, diagnostics, management and prevention. The findings are now published as «Navigating the Evolving Landscape of Atopic Dermatitis: Challenges and Future Opportunities: the 4th Davos Declaration».

Annual Report CK-CARE 2023

CK-CARE’s work has global resonance and, thanks to this strong position, significant projects in clinical allergy research were again launched or catalysed in the reporting year. CK-CARE’s working methods were sharpened in terms of medical translation and a strengthening of research capacities on the medical campus in Davos was defined in order to increase CK-CARE’s performance.

Annual Report 2023

CK-CARE’s work now has global resonance and, thanks to this strong position, significant projects in clinical allergy research were again launched or catalysed in the reporting year. CK-CARE’s working methods were sharpened in terms of medical translation and a strengthening of research capacities on the medical campus in Davos was defined in order to increase CK-CARE’s performance.

Kühne-Foundation Annual Report 2023

“Entrepreneurial success should go hand in hand with the promotion of  the common good. The Kühne Foundation fulfills this task. With a variety of programs and projects, the founder and the Kühne Foundation also assume their socio-political responsibility.”

The activities were significantly expanded, particularly in the area of logistics. In addition, the new focus area of climate action was established, and the first projects were launched.

Prof. Dr. h.c. Klaus-Michael Kühne

 

How flexible are neutrophils to opposing signaling?

Paola Martinez Murillo a postdoctoral researcher in Pierre-Yves Mantel’s group from CK-CARE obtained a Spark grant from the SNSF to investigate the effect of opposite signals on neutrophil biology in atopic dermatitis.

Spark is a Swiss National Science Foundation (SNSF) funding scheme aiming to support projects that show unconventional thinking and introduce a unique approach. The Spark is highly competitive and supports projects based on promising ideas of high originality. CK-CARE was recognized as an eligible institution in June 2023 by the SNSF, opening new funding opportunities for the CK-CARE researchers.

This project aims to understand how two opposing signals: eczema dysregulated immune environment (Th2 response) and bacterial colonization (Th1 response) impact neutrophils function.

Neutrophils are tiny but powerful immune cells in our blood that fight off bacteria and viruses. They live for only 2-3 days and can quickly respond to infections. Neutrophils can adapt to different situations thanks to their genetic instructions (RNA). Our body’s reversible changes in reading DNA, called epigenomic modifications, are crucial for a functional immune response.

Eczema, a chronic skin condition, happens when various factors like genetics, skin damage, and immune reactions go haywire. People with eczema have neutrophils that do not work as well in fighting bacteria, making them more prone to infections.

This study addresses a knowledge gap in neutrophil adaptation to an allergic milieu, by evaluating neutrophil adaptation to anti-bacterial response in a type 2 immune response dominated context such as atopic dermatitis using transcriptional and epigenomic profiling along with comprehensive analysis of neutrophil functionality (netosis, phagocytosis, ROS-production, bactericidal activity, chemotaxis). Building upon in-vitro stimulation insights, then we will aim for a comprehensive analysis of neutrophil functionality in atopic dermatitis patients treated or not with Dupilumab.

Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort

The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We conducted a cross-sectional study to investigate local environmental exposure and concomitant prevalence of allergic sensitization among local school children born and raised in an alpine environment.

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